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--- en:studie [2013/01/08 18:23]
80.86.255.130 [Basic research, laboratory models]
+++ en:studie [2013/03/23 23:07]
pistus Bacterial studies
@@ Line 4: / Line 4: @@
-  * __**Database of studies:**__ CAM-QUEST Database  - //includes more than 700 studies// - [[http://www.cam-quest.org/en/search/therapies/?l1=403]]
+  * __**Database of studies:**__ CAM-QUEST Database -- //includes more than 700 studies// -- [[http://www.cam-quest.org/en/search/therapies/?l1=403]]
-Piltan D. et al. "Test of a homeopathic dilution of Aconitum napellus. A clinical, randomized, double-blind, controlled crossover study in healthy volunteers." Forsch Komplementmed. 2009 Jun;16(3):168-73. Epub 2009 Jun 5. - [[http://www.ncbi.nlm.nih.gov/pubmed/19657201|http://www.ncbi.nlm.nih.gov/pubmed/19657201]]
+Piltan D. et al. "Test of a homeopathic dilution of Aconitum napellus. A clinical, randomized, double-blind, controlled crossover study in healthy volunteers." Forsch Komplementmed. 2009 Jun;16(3):168-73. Epub 2009 Jun 5. -- [[http://www.ncbi.nlm.nih.gov/pubmed/19657201|http://www.ncbi.nlm.nih.gov/pubmed/19657201]]
-Möllinger H, Schneider R, Walach H. "Homeopathic pathogenetic trials produce specific symptoms different from placebo." Forsch Komplementmed. 2009 Apr;16(2):105-10. Epub 2009 Apr 9. - [[http://www.ncbi.nlm.nih.gov/pubmed/19420956|http://www.ncbi.nlm.nih.gov/pubmed/19420956]]
+Möllinger H, Schneider R, Walach H. "Homeopathic pathogenetic trials produce specific symptoms different from placebo." Forsch Komplementmed. 2009 Apr;16(2):105-10. Epub 2009 Apr 9. -- [[http://www.ncbi.nlm.nih.gov/pubmed/19420956|http://www.ncbi.nlm.nih.gov/pubmed/19420956]]
+Walach H, Möllinger H, Sherr J, Schneider R. "Homeopathic pathogenetic trials produce more specific than non-specific symptoms: results from two double-blind placebo controlled trials." J Psychopharmacol. 2008 Jul;22(5):543-52. -- [[http://www.ncbi.nlm.nih.gov/pubmed/18701641|http://www.ncbi.nlm.nih.gov/pubmed/18701641]]
+Bracho G et al. 2010 - "Large-scale application of highly-diluted bacteria for Leptospirosis epidemic
+control." Homeopathy. 2010 Jul;99(3):156-66. [[http://www.ncbi.nlm.nih.gov/pubmed/20674839]]
-Walach H, Möllinger H, Sherr J, Schneider R. "Homeopathic pathogenetic trials produce more specific than non-specific symptoms: results from two double-blind placebo controlled trials." J Psychopharmacol. 2008 Jul;22(5):543-52. - [[http://www.ncbi.nlm.nih.gov/pubmed/18701641|http://www.ncbi.nlm.nih.gov/pubmed/18701641]]
 ==== Complex meta-analysis ====
-Bornhöft G. et al. "Effectiveness, safety and cost-effectiveness of homeopathy in general practice - summarized health technology assessment." Forsch Komplementmed. 2006;13 Suppl 2:19-29. Epub 2006 Jun 26. -- [[http://www.ncbi.nlm.nih.gov/pubmed/16883077|http://www.ncbi.nlm.nih.gov/pubmed/16883077]]
+Mathie RT et al. (2013) --//list of randomised controlled trials of homeopathy in humans, until 2011, 263 studies//-- "Randomised controlled trials of homeopathy in humans: characterising the research journal literature for systematic review." Homeopathy. 2013 Jan;102(1):3-24.([[http://www.ncbi.nlm.nih.gov/pubmed/23290875]])
+Bornhöft G. et al. "Effectiveness, safety and cost-effectiveness of homeopathy in general practice -- summarized health technology assessment." Forsch Komplementmed. 2006;13 Suppl 2:19-29. Epub 2006 Jun 26. -- [[http://www.ncbi.nlm.nih.gov/pubmed/16883077|http://www.ncbi.nlm.nih.gov/pubmed/16883077]]
+//__comments on Bornhöft study:__//
+//Shaw DM. The Swiss report on homeopathy: a case study of research misconduct. Swiss Med Wkly. 2012 May 31;142:w13594. [[http://www.smw.ch/content/smw-2012-13594/]] //
+//Reply to Shaw DM: von Ammon K, Bornhöft G, Maxion-Bergemann S, Righetti M, Baumgartner S,Thurneysen A, Wolf U, Matthiessen PF. Familiarity, objectivity - and misconduct: Counterstatement to Shaw DM. The Swiss Report on homoeopathy: a case study of research misconduct. Swiss Med Wkly. 2012;142:w13594. [[http://www.smw.ch/content/smw-2013-13720/]] //
+**Meta-analysis of financial costs**
+Viksveen P, Dymitr Z, Simoens S. Economic evaluations of homeopathy: a review. Eur J Health Econ. 2013 Feb 10.([[http://www.ncbi.nlm.nih.gov/pubmed/23397477]])
 ==== Effects of highly-diluted substances on animals ====
-  * __**Database of studies:**__ HomVetCR Database - Veterinary Clinical Research-Database in Homeopathy - //includes about 300 studies// - [[http://www.carstens-stiftung.de/clinresvet/index.php]]
+  * __**Database of studies:**__ HomVetCR Database -- Veterinary Clinical Research-Database in Homeopathy -- //includes about 300 studies// -- [[http://www.carstens-stiftung.de/clinresvet/index.php]]
+Clausen J et al. -- //review study, 48 studies from 1832-2009// -- "Infection models in basic research on homeopathy". Homeopathy. 2010 Oct;99(4):263-70. ([[http://www.ncbi.nlm.nih.gov/pubmed/20970096]])
 Endler et al. "Treatment of lowland frogs from the spawn stage with homeopathically prepared thyroxin (10(-30))." ScientificWorldJournal. 2007 Oct 22;7:1697-702. -- [[http://www.ncbi.nlm.nih.gov/pubmed/17982565|http://www.ncbi.nlm.nih.gov/pubmed/17982565]]
@@ Line 32: / Line 52: @@
   * __**Database of experiments:**__ HomBRex database -- The Homeopathic Basic Research experiments database -- //includes more than 1700 experiments in 1300 papers// - [[http://www.carstens-stiftung.de/hombrex]]
-Endler et al. (2010) - //review, repeated experiments in basic research, 107 studies, 24 models// -- "Repetitions of fundamental research models for homeopathically prepared dilutions beyond 10(-23): a bibliometric study." Homeopathy. 2010 Jan;99(1):25-36.([[http://www.ncbi.nlm.nih.gov/pubmed/20129174]])
+Endler et al. (2010) -- //review, repeated experiments in basic research, 107 studies, 24 models// -- "Repetitions of fundamental research models for homeopathically prepared dilutions beyond 10(-23): a bibliometric study." Homeopathy. 2010 Jan;99(1):25-36.([[http://www.ncbi.nlm.nih.gov/pubmed/20129174]])
+  * **Animal studies**
+//assumptions for study selection://
+//- use of high potencies (12CH and more)//
+//- blinded conditions//
+//__effects on physiological functions:__//
+Ruiz-Vega et al. (2005)-- "Histamine at high dilution reduces spectral density in delta band in sleeping rats". Homeopathy (2005), Vol. 94(2), pp. 86-91 ([[http://www.ncbi.nlm.nih.gov/pubmed/15892488]])
+Welles et al. (2007)-- "Pretreatment with thyroxin 10(-8) and the effect of homeopathically prepared thyroxin 10(-30) on highland frogs--a multi-researcher study." Forsch Komplementärmed (2007), Vol. 14(6), pp. 353-357 ([[http://www.ncbi.nlm.nih.gov/pubmed/18219210]])
+Weber et al. (2008)-- "The effect of homeopathically prepared thyroxine on highland frogs: influence of electromagnetic fields". Homeopathy (2008), Vol. 97(1), pp. 3-9 ([[http://www.ncbi.nlm.nih.gov/pubmed/18194759]])
+de Oliviera et al. (2011)--"Mercurius solubilis: actions on macrophages". Homeopathy (2011), Vol. 100(4), pp. 228-236 ([[http://www.ncbi.nlm.nih.gov/pubmed/21962197]])
+Kiefer et al. (2012) --"Lowland amphibians - recalculation of data on effects of diluted thyroxine".
+Int J High Dil Res (2012), Vol. 11(38), pp. 3-18 ([[http://www.feg.unesp.br/~ojs/index.php/ijhdr/article/view/526]])
+//Negative findings://
+Velkers et al. (2005)-- "Isopathic and pluralist homeopathic treatment of commercial broilers with experimentally induced colibacillosis" Res Vet Science (2005), Vol. 78(1), pp. 77-83([[http://www.ncbi.nlm.nih.gov/pubmed/15500843]])
+Siegling-Vlitakis et al. (2009)-- "In vitro examination of potentized atropine sulfate dilutions on the contractility of the isolated rat ileum". J Altern Complement Med (2009), Vol. 15(10), pp. 1121-1126([[http://www.ncbi.nlm.nih.gov/pubmed/19824820]])
+//__effects on animal emotions:__//
+Magnani et al. (2010) --"Dose-effect study of Gelsemium sempervirens in high dilutions on anxiety-related responses in mice". Psychopharmacology (2010), Vol. 210(4), pp. 533-545 ([[http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2877813/]])
+Bellavite et al. (2011)-- "Effects of high-dilutions in behavioural models: a commentary on critical issues, from reproducibility to plausibility". Int J High Dilution Res 2011; 10(37): 325-337 ([[http://www.feg.unesp.br/~ojs/index.php/ijhdr/article/viewFile/532/550]])
+Bellavite et al. (2012) --"Testing homeopathy in mouse emotional response models: pooled data analysis of two series of studies". eCAM (2012), Vol. Article ID 954374, pp. 1-9 ([[http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3324905/]])
+Heine et al. (2012) --"Assessment of homeopathic medicine Aconitum napellus in the treatment of anxiety in an animal model". Int J High Dilution Res 2012; 11(38):33-42 ([[http://www.feg.unesp.br/~ojs/index.php/ijhdr/article/viewArticle/547]])
+//__effects on animal diseases and toxicological studies:__//
+Clausen J et al. -- //review study, 48 studies from 1832-2009// -- "Infection models in basic research on homeopathy". Homeopathy. 2010 Oct;99(4):263-70. ([[http://www.ncbi.nlm.nih.gov/pubmed/20970096]])
+//later or selected older studies://
+Biswas et al. (2005)--"Efficacy of the potentized homeopathic drug, Carcinosin 200, fed alone and in combination with another drug, Chelidonium 200, in amelioration of p-Dimethylaminoazobenzene-induced hepatocarcinogenesis in mice". J Altern Complement Med (2005), Vol. 11(5), pp. 839-854 ([[http://www.ncbi.nlm.nih.gov/pubmed/16296917]])
+Paula Coelho et al. (2006)-- "Therapeutic and pathogenetic animal models for Dolichos pruriens". Homeopathy (2006), Vol. 95(3), pp. 136-143([[http://www.ncbi.nlm.nih.gov/pubmed/16815516]])
+Jonas et al. (2006)-- "Can homeopathic treatment slow prostate cancer growth?" Integr Cancer Ther (2006), Vol. 5(4), pp. 343-349 ([[http://www.ncbi.nlm.nih.gov/pubmed/17101763]])
+MacLaughlin et al. (2006)-- "Effects of homeopathic preparations on human prostate cancer growth in cellular and animal models". Integr Cancer Ther (2006), Vol. 5(4), pp. 362-372 ([[http://www.ncbi.nlm.nih.gov/pubmed/17101766]])
+Banerjee et al. (2007)-- "A potentized homeopathic drug, Arsenicum album 200, can ameliorate genotoxicity induced by repeated injections of arsenic trioxide in mice". J Vet Med (A) (2007), Vol. 54(7), pp. 370-376([[http://www.ncbi.nlm.nih.gov/pubmed/17718811]])
+Pathak et al. (2007)-- "Supportive evidence for the anticancerous potential of alternative medicine against hepatocarcinogenesis in mice". Forsch Komplementärmed (2007), Vol. 14(3), pp. 148-156 ([[http://www.ncbi.nlm.nih.gov/pubmed/17596695]])
+Bhattacharjee et al. (2009)-- "Homeopathic drugs Natrum sulphuricum and Carcinosin prevent azo dye-induced hepatocarcinogenesis in mice". Indian J Biochem Biophys (2009), Vol. 46(4), pp. 307-318 ([[http://www.ncbi.nlm.nih.gov/pubmed/19788063]])
+Bhattacharjee et al. (2009)-- "Amelioration of carcinogen-induced toxicity in mice by administration of a potentized homeopathic drug, Natrum sulphuricum 200". eCAM (2009), Vol. 6(1), pp. 65-75 ([[http://www.hindawi.com/journals/ecam/2009/521217/abs/]])
+Goncalves de Araujo et al. (2009)-- "Effect of Mercurius solubilis on the bacteriological response in the alveolitis process in rats". Homeopathy (2009), Vol. 98(3), pp. 160-164 ([[http://www.ncbi.nlm.nih.gov/pubmed/19647210]])
+Kuzeff et al. (2009)-- "Isopathic versus enantiomeric inhibition of U-50488 HCl toxicity" Homeopathy (2009), Vol. 98(2), pp. 83-87 ([[http://www.ncbi.nlm.nih.gov/pubmed/19358960]])
+Pathak et al. (2009)-- "Combinational homeopathic therapy reduces genotoxicity and cytotoxicity in mice fed carcinogenesis". Clin Exp Hom (2009), Vol. 1(1), pp. (1-10) ([[http://www.sukulhomeopathy.com/newjournal/khuda-buksh1.pdf]])
+Viriato et al. (2009)-- "Study of high dilution of copaiba oil on inflammatory process". Int J High Dil Res (2009), Vol. 8(26), pp. 9-14 ([[http://www.feg.unesp.br/~ojs/index.php/ijhdr/article/viewFile/305/380]])
+Banerjee et al. (2010)-- "Chelidonium majus 30C and 200C in induced hepato-toxicity in rats". Homeopathy (2010), Vol. 99(3)([[http://www.ncbi.nlm.nih.gov/pubmed/20674840]])
+Ghilosso-Bortolini et al. (2010)-- "Putative protective effect of Cadmium chloride high diluted solution on LLC-PK1 cell intoxicated by high concentration of this same metal". Int J High Dil Res (2010), Vol. 9(30), pp. 16-29 ([[http://www.feg.unesp.br/~ojs/index.php/ijhdr/article/viewArticle/381]])
+Banerjee et al. (2011)-- "Evidences of protective potentials of microdoses of ultra-high diluted arsenic trioxide in mice receiving repeated injections of arsenic trioxide". eCAM (2011), Vol. 2011 ([[http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3135423/]])
+Patil et al. (2011)-- "Modulation of arthritis in rats by Toxicodendron pubescens and its homeopathic dilutions". Homeopathy (2011), Vol. 100(3) ([[http://www.ncbi.nlm.nih.gov/pubmed/21784329]])
+Bhattacharjee, Khuda-Bukhsh (2012)-- "Two homeopathic remedies used intermittently provide additional protective effects against hepatotoxicity induced by carcinogens in mice" J Acupunct Meridian Stud (2012), Vol. 5(4), pp. 166-175 (http://www.ncbi.nlm.nih.gov/pubmed/22898065)
+Mohammadi et al. (2012)-- "Homeopathic treatment for peripheral nerve regeneration: an experimental study in a rat sciatic nerve transection model." Homeopathy (2012), Vol. 101(3), pp. 141-146 ([[http://www.ncbi.nlm.nih.gov/pubmed/22818230]])
+Patel et al. (2012)-- "Toxicodendron pubescens retains its anti-arthritic efficacy at 1M, 10M and CM homeopathic dilutions." Homeopathy (2012), Vol. 101(3), pp. 165-170 ([[http://www.ncbi.nlm.nih.gov/pubmed/22818234]])
+//Negative findings://
+Almeida et al. (2009)-- "Homeopathic treatment for bone regeneration: experimental study." Homeopathy (2009), Apr;98(2):92-6. ([[http://www.ncbi.nlm.nih.gov/pubmed/19358962]])
+  * **Bacterial studies**
+Saha et al. (2012) -- "Phenotypic evidence of ultra-highly diluted homeopathic remedies acting at gene expression level: a novel probe on experimental phage infectivity in bacteria" Journal of Chinese Integrative Medicine (2012), Vol. 10(4), pp. 462-470 ([[http://www.ncbi.nlm.nih.gov/pubmed/22500721]])
+Das S et al. (2012) -- "Potential of the homeopathic remedy, Arnica Montana 30C, to reduce DNA damage in Escherichia coli exposed to ultraviolet irradiation through up-regulation of nucleotide excision repair genes. Zhong Xi Yi Jie He Xue Bao. 2012 Mar;10(3):337-46. ([[http://www.ncbi.nlm.nih.gov/pubmed/22409925]])
+De A et al. (2012) -- "Potentized homeopathic drug Arsenicum album 30C inhibits intracellular reactive oxygen species generation and up-regulates expression of arsenic resistance gene in arsenine-exposed bacteria Escherichia coli" J Chin Integr Med (2012), Vol. 10(2), pp. 210-227 ([[http://www.jcimjournal.com/en/FullText2.aspx?articleID=jcim20120212]])
   * **Studies on plants**
@@ Line 51: / Line 165: @@
 Apr;17(2):63-70.([[http://www.ncbi.nlm.nih.gov/pubmed/19185263]])
-Bonato et al. (2009) - "Homeopathic drugs Arsenicum album and Sulphur affect the growth and essential oil content in mint (Mentha arvensis L.)" Acta Scientarum Agronomy (2009), Vol. 31(1), pp. 101-105([[http://periodicos.uem.br/ojs/index.php/ActaSciAgron/article/view/6642]])
+Bonato et al. (2009) -- "Homeopathic drugs Arsenicum album and Sulphur affect the growth and essential oil content in mint (Mentha arvensis L.)" Acta Scientarum Agronomy (2009), Vol. 31(1), pp. 101-105([[http://periodicos.uem.br/ojs/index.php/ActaSciAgron/article/view/6642]])
-Gangar (2010) - "Management of genetic activity through homoeopathy." Int J Pharma Bio Sci (2010), Vol. 1(2), pp. 1-13([[http://www.ijpbs.net/issue-2/177.pdf]])
+Gangar (2010) -- "Management of genetic activity through homoeopathy." Int J Pharma Bio Sci (2010), Vol. 1(2), pp. 1-13([[http://www.ijpbs.net/issue-2/177.pdf]])
-Pfleger et al. (2011) - "The effect of extremely diluted agitated gibberellic acid (10e-30) on wheat stalk growth-A two researcher pilot study." Complement Ther Med. 2011 Jun;19(3):164-9. Epub 2011 May 20. - [[http://www.ncbi.nlm.nih.gov/pubmed/21641523|http://www.ncbi.nlm.nih.gov/pubmed/21641523]]
+Pfleger et al. (2011) -- "The effect of extremely diluted agitated gibberellic acid (10e-30) on wheat stalk growth-A two researcher pilot study." Complement Ther Med. 2011 Jun;19(3):164-9. Epub 2011 May 20. - [[http://www.ncbi.nlm.nih.gov/pubmed/21641523|http://www.ncbi.nlm.nih.gov/pubmed/21641523]]
-Kiefer ET AL. (2012) -- "Wheat germination and highly diluted agitated gibberellic acid (10 -30) - a multi researcher study". Int J High Dil Res (2012), Vol. 11(39), pp. 45-59([[http://www.feg.unesp.br/~ojs/index.php/ijhdr/article/view/428]])
+Kiefer ET AL. (2012) -- "Wheat germination and highly diluted agitated gibberellic acid (10 -30) -- a multi researcher study". Int J High Dil Res (2012), Vol. 11(39), pp. 45-59([[http://www.feg.unesp.br/~ojs/index.php/ijhdr/article/view/428]])
 //__effects on plant diseases:__//
@@ Line 65: / Line 179: @@
 //later or selected older studies://
-Datta (2006) - "Effects of Cina on root-knot disease of mulberry." Homeopathy. 2006 Apr;95(2):98-102.([[http://www.ncbi.nlm.nih.gov/pubmed/16569626]])
+Datta (2006) -- "Effects of Cina on root-knot disease of mulberry." Homeopathy. 2006 Apr;95(2):98-102.([[http://www.ncbi.nlm.nih.gov/pubmed/16569626]])
 Sukul et al. (2006) -- "Amelioration of root-knot disease of lady's finger plants by potentized Cina and Santonin." Homeopathy. 2006 Jul;95(3):144-7.([[http://www.ncbi.nlm.nih.gov/pubmed/16815517]])
@@ Line 88: / Line 202: @@
 Jäger et al. (2010) -- "Effects of homeopathic arsenicum album, nosode, and gibberellic acid preparations on the growth rate of arsenic-impaired duckweed (Lemna gibba L.)" Scientific World J (2010), Vol. 10, pp. 2112-2129([[http://www.hindawi.com/journals/tswj/2010/107597/abs/]])
-Bonfim et al. (2010) - " Germination and vigor of lettuce seeds (Lactuca sativa L.) pelleted with homeopathic preparations Alumina and Calcarea carbonica subjected to toxic levels of aluminum". Int J High Dil Res (2010), Vol. 9(33), pp. 138-146 ([[http://www.feg.unesp.br/~ojs/index.php/ijhdr/article/viewFile/412/450]])
+Bonfim et al. (2010) -- " Germination and vigor of lettuce seeds (Lactuca sativa L.) pelleted with homeopathic preparations Alumina and Calcarea carbonica subjected to toxic levels of aluminum". Int J High Dil Res (2010), Vol. 9(33), pp. 138-146 ([[http://www.feg.unesp.br/~ojs/index.php/ijhdr/article/viewFile/412/450]])
 Brizzi et al. (2011) -- "The efficacy of ultramolecular aqueous dilutions on a wheat germination model as a function of heat and aging-time". eCAM (2011), Vol. 2011, pp. 696298; (1-11)([[http://www.hindawi.com/journals/ecam/2011/696298/]])
@@ Line 106: / Line 220: @@
 van Wijk R et al. (2006) -- "Thermoluminescence in ultra-high dilution research." J Altern Complement Med. 2006 Jun;12(5):437-43.([[http://www.ncbi.nlm.nih.gov/pubmed/16813507]])
-Rey L. (2007) - "Can low-temperature thermoluminescence cast light on the nature of ultra-high dilutions?" Homeopathy (2007), Vol. 96(3), pp. 170-174. ([[http://www.ncbi.nlm.nih.gov/pubmed/17678813]])
+Rey L. (2007) -- "Can low-temperature thermoluminescence cast light on the nature of ultra-high dilutions?" Homeopathy (2007), Vol. 96(3), pp. 170-174. ([[http://www.ncbi.nlm.nih.gov/pubmed/17678813]])
   * **Spectroscopy**

Legatum Homeopathicum

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