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Bufo Rana. (Bufones.)

Toads. Reptilia.

Toads belong to the most poisonous reptiles.

In olden times, being looked upon as horrible things, they were given in horrible diseases. During the rage of improvement the remedy was thrown overboard, and even the poisonous qualities doubted, until rare experiments, especially those by Vulpian, have settled the question. In 1832 Henke, our great prover, was the first in our school to call attention to it; his observations were published in Meyer's Monatsblatt, 1860; in 1834 the Homeopathic Society of Thringen sent some symptoms to the Archives of Stapf (vol. xiv, No. 2, page 102). In 1849 Mure published a proving with his preparation, taken from the most common toad in Brazil, called by him Bufo satyhiensis. This was translated by Hempel and Allen. Houat published one of his provings in Nouvelles Donnes. This was translated three times –by Lippe, Lilienthal and Allen. In 1859, Destrone, in a French journal, collected notes from all old writers and also made some provings. His collection has been translated in Allen's Encyclopaedia, including the very doubtful numbers 6, 7 and half of 8. The provers mentioned have used about half a dozen different species, and nearly every one proved a different preparation. The cures are of the greatest importance and cannot be doubted in the least, even not by such who make profession of so-called skepticism. But now for nearly ten years we have not been able to find a single case in our journals. The cures have been epilepsy, cancers, beginning of malacie of the brain and cutaneous diseases. Many of Houat's symptoms have been verified.

The best way of getting the poison was proposed in 1861 by Roth in Paris, Allg. H. Zeit, vol. vi, page 112, mentioned in Schwabe's Pharmacopoeia, by faradization; but in 1862, in C. Müller's Quarterly, vol. xiii, the same author proposed a still better one. The toad was to be held with the left hand in a wooden forceps, the glands on the side of head pressed with a wire forceps and the juice caught on a glass plate; it is soluble in alcohol.

MIND. [1]

Desire for solitude, to practice masturbation.
Whimpered, then cried, until he fell into a state of coma.
Left his bed after apathy and ran like mad through the house, constantly howling; eyes injected; tongue dry; pulse regular; no febrile heat.
Weak memory; idiotic. ~ Spasms.
Delirium or apathy, with hot head.
Mind not affected. ~ Epilepsy.
Longs for solitude, yet dreads being alone. See 22.
Inclination to be angry, to bite.
Bites at surrounding objects.
Easily laughs or cries; cries much. ~ Epilepsy.
Fear of disease, of animals, of death.
Great anguish. ~ Meningitis.
Ill humor. See 23.
Becomes angry if misunderstood; before spasms.
Easily startled.


Vertigo, as if house was turned up side down.
Giddiness, with heaviness of head.
Vertigo, spasms, fainting followed by death.
Attacks were ushered in by numbness of brain. ~ Epilepsy.
Stupor and inability to speak.
Apathy following coma.


Pressure like two iron hands holding temples.
Headache: after breakfast; aggravated by light and noise; accompanied by cold feet and palpitation at heart; one-sided (r. side), relieved by bleeding of nose.
Dull headache in left side. ~ Softening of brain.
Headache, with epilepsy.
Violent orgasm in head.
Congestive headache, with flushed face. ~ Epilepsy.


Headache in forehead and on vertex; parts tender to touch, especially in evening.
Lancinations in occiput, inclining head to fall backward. ~ Meningitis.
Continued agitation of head and arms.
Head was at first drawn to one side, either right or left, then backward, before an attack. ~ Epilepsy.
Profuse perspiration on head.
Hair falls out.


Cannot bear sight of brilliant objects.
Objects appear as if seen through a veil.
More acute vision, and eyes less sensitive to wind.
Itching in eyes, with dimness of sight.
Pupils largely dilated and unaffected by light before attack. ~ Epilepsy.
Ugly squinting look.
Eyes red, injected; itching, swollen, painful.
Spasmodic pain in eye, which appeared slightly injected.
Burning, itching and ulceration of lids, especially at canthi.
Eyes became highly injected; shrunken and lifeless in appearance, as the attacks multiplied. ~ Epilepsy.
Right eye open, left nearly closed; eyeballs rolled upward and to left before attack. ~ Epilepsy.
Left lid paralyzed, hangs down. ~ Softening of brain.
Edges of eyelids red and some crusts in lashes. ~ Epilepsy.
A whitish crust over eyebrows.
Eyes sunken during spasm. ~ Epilepsy.
Incapable of opening lids, in coma.


Least noise is disagreeable; music is unbearable.
Beating in heart reverberates in ears. ~ Meningitis.
Hardness of hearing, especially for words.
Purulent otorrhea; ulceration and bleeding of external ears; pains worse from cold washing. See 8 and 12.
Swelling of ears and parotids.


Loss of smell.
Epistaxis almost producing faintness; relieves headache.
Sneezing in evening, when going to bed; coryza; pimples on upper lip.
Running of greenish-yellow, putrid mucus; agg. evening; cold air causes a feeling of corrosion.
Ulcerated, burning nostrils Mucus descends into posterior nares.


Face much altered.
Distortion and turgescence of face; mouth and eyes convulsed; profuse sweat on face.
First muscles of face commenced to twitch, extending thence over whole body. ~ Epilepsy.
Face greyish; red, bloated during spasms.
Cold water causes a pricking of face. See 6, 12.
Momentary hot flushes of face.
Copious sweat running down face.
Burning and redness of swollen face.
Phlegmonous erysipelas, which leaves face deformed.
Face bathed in sweat during spasm. ~ Epilepsy.


Pimples on upper lip, with coryza.


Falling out of teeth.


Difficult mobility of tongue, it paralyzes rapidly; irritability of tongue and other muscles.
A kind of lapping motion of tongue, feeling of face and rubbing of nose before attacks. ~ Epilepsy.
Stuttering; stammering; gets angry when incoherent speech is not understood. ~ Chorea.
Stupor and inability to talk.
Bites the tongues.
Dry tongue.
Tongue cracked, bluish-black.
Lips and tongue black.


Fetid odor from mouth.
Mouth wide open before an attack. ~ Epilepsy.
Mouth burning, as from acid; worse from cold water.
Sanguinolent salivation.
Bloody saliva. ~ Spasms.
During violent agitation of muscular system, ejection of frothy, bloody saliva from mouth. ~ Epilepsy.
Carried objects within his reach to his mouth to bite them.


Mucus descends from nose into posterior nares.
Dryness in throat, impeding deglutition (morning).
Difficult swallowing, can hardly swallow saliva.
Convulsive and constrictive motion in throat, with a sensation like a stone there.
Fearful sore throat, could eat neither supper nor breakfast for it; verified at another time in same person.
Eruption in pharynx, like spots on skin. ~ Epilepsy.


Desire for sugar-water.
Desire for sweetened water and milk, yet they cause nausea and colic.
Longing for brandy; delights in getting drunk.
Aversion to food and drink.


Dizzy, drunken feeling after dinner.
Sleepiness after meals, especially after dinner. See 4.
After eating, irresistible sleepiness.
Colicky pain after drinking milk, and after smoking tobacco.


Eructations, as from rotten eggs.
Nausea and vomiting after the swelling.
Nausea in morning for a week.
Vomiting after drinking.
Yellow fluid in vomit, like that from eruption. ~ Epilepsy.
Vomiting of bile or of blood; burning, cramping in stomach.
Nervous excitement, with nausea and vomiting.


Sensation as if he would faint, from emptiness in stomach.
Weak, faint feeling in stomach. See 36.
Burning in stomach; lancinating pains radiating to liver and heart.


Rapid motion of diaphragm.
Pulsating, laming pain in liver, like an abscess; vomiting of bile.
Enlargement of liver.


Colicky pains after milk, or from smoking tobacco.
Violent colic, with convulsive movements of jaws and limbs.
Spasms end by convulsive movements in abdomen.
The attack originates in abdomen. ~ Epilepsy.


Dysentery, with delirium, headache and sleeplessness.
Bowels torpid.
Stools white.
Difficult, hard stool, with cold body and hot head.
Hemorrhoidal tumors, with discharge of bright red blood.


Burning pain in kidneys, with oppressed breathing and faintness.
Urine passes off involuntarily. ~ Softening of brain.
Frequent discharge of pale urine.
During violent agitation of entire muscular system, discharge of urine. ~ Epilepsy.
Urine brown, of offensive odor.
Suppression of urine.


Inclination to touch genitals.
Desire for solitude to practice onanism.
Involuntary seminal emission.
Impotence; semen is ejaculated too quickly, or fails entirely.
Semen in discharged too quickly, without pleasurable sensation, sometimes with cramps or painful heaviness in limbs.
Impotence of worst kind; produced in some and cured in others.
Spasms during coition.


Burning and swelling of ovaries.
Burning heat and stitches in ovaries.
Swelling and great sensitiveness of ovarian region.
Violent cramps in ovarian region, extending into groins.
Hydatids in ovaries.
Epileptic aura from uterus towards stomach.
Distending, burning pains or cramps in uterus; sharp, dagger-like pains; worse on walking or sitting too long. ~ Carcinoma uteri.
Ulceration of cervix uteri, with burning pains; offensive, purulent leucorrhea.
Enormous blisters on tumefied uterus, discharging a thin, serous, yellow fluid. ~ Epilepsy.
Menses: suppressed (epilepsy); regular but rather scanty (epilepsy); too early, with headache; too early, preceded by headache, burning in uterus and vagina.
Spasms occur just before menses. ~ Epilepsy.
Attacks worse at time of menses, which return every three weeks. ~ Epilepsy.
During menses, contractive pain in liver, palpitation; shivering in legs.
After menses, ill-humored.
Yellow fluid in leucorrhea, like from eruption. ~ Epilepsy.


Haematuria in childbed.
Inflammation of mamma; purulent sinuses; sensation as if breasts were torn towards belly.
(OBS:) Puerperal convulsions if suppuration is suspected.
Cancer mamma occultus.
Mammary cancer.
Milk mixed with blood.
Tumefaction like a cord from groin to knee. ~ Milk leg.
Child became epileptic in consequence of mother having a fright or fit of anger during nursing period.


Burning, excoriation in larynx; bleeding fissures, causing quick, jerking cough.


After convulsive movements became less rapid and violent, breathing became heavy and stertorous, with usual puffing of lips at every expiration, directly culminated in a deep-drawn sigh, and patient sank into coma, soon followed by the restlessness and convulsions as before. ~ Epilepsy.
Difficult breathing from compression of larynx, trachea and heaviness of chest; must sit up or bend forward. See 21.
Sensation as if chest and heart were constricted.
Breathing anxious, difficult, gets shorter and shorter, with fever.
Dyspnea; pants like a dog.

COUGH. [27]

Cough from any emotion.
Cough from burning or stitches in larynx.
Cough nocturnal, provoked towards 3 or 4 A. M. by a tickling in larynx, which he feels only at this hour.
Cough in consequence of cold feet.
Violent cough, with vomiting.
Cough dry, with sharp pain or burning in chest.
Sputa mucous or sanguinolent, or formed of pure blood, raised most in morning and evening, with sensation of cold in chest; a sensation which is often succeeded by heat and congestion.


Stitches in chest (r. side).
Burning like fire in lungs.
Laryngitis, haemoptysis, phthisis pulmonalis.


Palpitation; with headache; after a meal; with nausea; during menses; on awaking; evening.
Palpitation and oppression from walking fast.
Sticking pains about apex of heart.
Heart feels as if too large, as if drowned in a basin of water.
Sense of constriction about heart and chest. See 3.
Heaviness about heart.
Paralysis of heart.
Pulse became more and more rapid and threadlike as the paroxysms multiplied. ~ Epilepsy.


Attacks ushered in by a jerk in nape of neck. ~ Epilepsy.
A swelling of bone size of fist. ~ Caries of dorsal vertebrae.


Great desire to exercise arms. See 36.
Burning, lancinating in bones of arms. See 44.
Arms became stiffened before an attack. ~ Epilepsy.
Arms go to sleep easily.
Numbness of left arm. ~ Epilepsy.
Swelling of wrists and finger joints, with burning and pulsating.
A blister in hand which recurred annually.
After a slight contusion of (little) finger, tearing pain, with redness along whole arm, following lymphatic vessels into armpit, causing there painful glandular swellings.
Contractions of fingers of right hand, then left, followed the lapping motion of tongue, with thumbs drawn into palms; before an attack. ~ Epilepsy.
Panaritium, swelling blue black around nail (thumb), followed by suppuration.
Panaritium; pains run in streaks all the way up arm.


Lower limbs are more in motion than upper.
Cramps in legs, awaking him from his sleep.
Legs drawn backward until they touch glutei.
Lower limbs straight and stiff before attack. ~ Epilepsy.
Lower limbs get weak, has to take first one stick, then two to be able to walk. ~ Softening of brain.
Great weakness of legs.
Shooting, boring in knees, ankles, feet; worse moving.
Swelling of knees, with pulsative and distending pains.


Limbs are very easily moved.
Contusive pains in arms, legs and loins, during movement.
Trembling of limbs; heaviness.
Cramps in limbs; worse in cold air.
Arthritic swelling.
Swelling of hands and arms; burning pains. ~ Erysipelas.
Large yellow blisters in palms and soles, of three inches circumference; the fluid oozing out is yellowish and corroding; repeatedly on several places.


Pain in limbs since months, he is bent and cannot walk without a stick. ~ Caries of dorsal vertebrae.
Each attack heralded by restless movements of limbs and body. ~ Epilepsy.
Sitting too long, uterine pains.
Must sit up: dyspnea.
Inclined to lie on left side.
Lying on back increases sufferings.
Walking: distending, burning pain or cramps in uterus; dagger-like pains agg.; fast, palpitation and apprehension.
Sitting: distensive, burning pain; cramps in uterus; dagger-like pains agg.; difficult breathing better.
Bending forward: difficult breathing better.
Motion: discharge of urine from violent agitation of muscular system; desire to exercise arms; lower limbs move more than upper; shooting, burning in knees, ankles and feet agg.; contusive pains in arms, legs and loins.

NERVES. [36]

Great muscular strength; prefers jumping to walking.
Great mobility of limbs.
Repeated shocks through whole body.
Up to period of beginning, muscles were in a state of tonic contraction, but then jactitations or twitchings commenced. ~ Epilepsy.
Twitching of muscles.
Twitching over whole body increased rapidly in severity, till entire muscular system became violently agitated. ~ Epilepsy.
Tonic and clonic spasms.
Spasms begin in solar plexus.
Loss of consciousness and falling down.
Convulsions. ~ Epilepsy (after fright).
Epilepsy after onanism. Compare Sulphur.
Spasms caused by or associated with suppuration of internal parts.
Convulsion of limbs. ~ Softening of brain.
Spasms: from fright; at new moon; after onanism; during coitus.
Before spasm: angry for several days; face greyish-yellow, eyes sunken; jerks in back of neck.
During attack: face distorted, red, biting tongue; bloody saliva; violent movements of limbs; profuse sweat.
After attack: spasmodic movements of intestines; profound sleep.
Subsultus tendinum.
Falls to ground unconscious, with a blood-curdling, wild cry, followed by spasms in limbs; distorted facial muscles, grinding teeth and foaming mouth; ending in loud, snoring sleep. ~ Epilepsy.
Spasms very severe, followed by sleep. ~ Epilepsy pain.
Attacks come on in sleep, are followed by severe pain and pressure in top of head. ~ Epilepsy.
Dreadful paroxysm several times a week. ~ Epilepsy.
Fifty paroxysms occurred during fifteen hours, with complete unconsciousness. ~ Epilepsy.
Trembling, faint, with a sensation of emptiness in stomach; tottering gait. See 33.
Great weakness; fainting.

SLEEP. [37]

Sleepiness: after meals; when he smokes tobacco in forenoon.
Sleepy, stupid after eating, or after having been in open air.
Sleepy, as if drunken; congestion to head.
Drowsy, but cannot sleep, from agitation; constantly turning in bed.
After a deep-drawn sigh, patient sank away into a comatose condition, from which no effort could rouse him. ~ Epilepsy.
Continued yawning, could not keep lips open.
Very profound coma subsequent to attacks. ~ Epilepsy.
Child cries and complains, finally becomes comatose.
Stupid sleep after epileptic attack.
Starts in sleep, awakens as if frightened; palpitation.
At midnight seized with convulsions, recurring every twenty minutes till 4 P. M. of next day.
On awaking, aggravation of all sufferings; neck stiff; arthritic pains.

TIME. [38]

Midnight: convulsions, returning every twenty minutes, till 4 P. M.
Morning: dryness in throat; nausea; mucous or sanguinolent sputa agg.; aggravation of all symptoms; neck stiff; arthritic pains; sweat towards morning.
Evening: headache in forehead and vertex; sneezing; putrid greenish-yellow mucus from nose agg.; mucous or sanguinolent sputa agg.; palpitation with headache; symptoms generally worse.
Attacks appear with change of moon. ~ Epilepsy.


The warm room is unpleasant.
Headache and flushed face much agg. in warm room or near stove; amel. from cold bathing or in cold air. ~ Epilepsy.
Putting feet in hot water and drinking something hot, sometimes breaks up the attack. ~ Epilepsy.
Great sensibility to open, cold air and wind. See 34, 37, 40.
Open air: coldness; moist skin; nervousness and trembling worse.
Cold: air causes corrosion of nostrils; water causes pricking of face; water, burning of mouth agg.; air, cramps in limbs.
Wind: eyes less sensitive to.

FEVER. [40]

Coldness and shivering, with moist skin, nervousness and trembling; agg. going into open air.
Heat, with apathy or delirium, and cold feet.
The limbs get cold, head and face increasingly hot, as paroxysms multiply. ~ Epilepsy.
Burning heat in various parts.
Limbs burning hot during fever.
Hot head, cold body; delirium or apathy; constipation.
Profuse, oily sweat on head and face.
Bathed in sweat, weak; spasms.
Sweat during sleep, towards morning.
The body, and especially hands and arms, bathed in a clammy perspiration, as attack multiplied. ~ Epilepsy.
Checked sweat, now very copious, most towards morning. ~ Softening of brain.
Cold sweat.
(OBS:) Plague.


Every week, on one day, four attacks. ~ Epilepsy.
About once on week, always in night, followed by some hours of coma. ~ Epileptic spasms.
Has from ten to twelve attacks yearly. ~ Epilepsy.
Attacks since about five years. ~ Epilepsy.


Right: eye open; stitches in chest.
Left: dull headache; eye nearly closed; lid paralyzed.


Vertigo as if house was turned upside down; heart as if too large, as if drowned in a basin of water; as if breasts were torn towards belly.
If awake she has some warning, from a feeling of general numbness, immediately followed by a spasm. ~ Epilepsy.
Lancinating: in occiput; in stomach to liver and heart; in bones of arms.
Stitching: in ovaries; in larynx; in chest, right side; about apex of heart; in skin.
Pricking: of face from cold water.
Shooting: in knees, ankles and feet.
Tearing: along arm.
Contusion: in arms, legs and loins during motion.
Pressure: like two iron bands holding temples; in top of head.
Aching: of head after meal; one-sided headache; of head with epilepsy; in forehead and vertex; of teeth; of head during menses.
Soreness: of throat.
Burning: of eyelids; of nostrils; of face; of mouth; in stomach; in kidneys; of ovaries; pain in uterus; in uterus and vagina; during menses; in larynx; in chest; like fire in lungs; in bones of arms; of wrists and finger joints; in knees, ankles and feet; in hands and arm; heat in various parts; of skin.
Pain: of eyes; spasmodic in eye; colic after drinking milk or smoking; dagger-like in uterus; in streaks up arm; arthritic pains on awakening.
Cramps: in ovarian region; in uterus; in legs.
Tenderness: of forehead and vertex; of ovarian region; of bones.
Twitching: of whole body.
Compression: of larynx, trachea.
Contraction: in liver; of chest and heart.
Constriction: about heart and chest.
Distension: in uterus; pain in knees.
Largeness of heart.
Emptiness: in stomach.
Heaviness: in limbs, from coition; of chest; about heart; of limbs.
Stone: sensation of, in throat.
Pulsating: pain in liver, abscess-like; of wrists and finger joints; pain in knees, with swelling.
Beating: in ear.
Weakness: of legs; great weakness and fainting.
Faintness: from epistaxis; in stomach.
Heat: of head and face.
Shivering: in legs.
Coldness: of feet, with headache; of feet, causing cough; in chest; of limbs, with moist skin.
Numbness: of brain; of left arm.
Tickling: in larynx.
Itching: in eyes, with dimness of sight; of eyelids; of lower limbs.
Dryness: of tongue; in throat.


Redness and swelling along course of lymphatics, after wounds, etc. See 24, 32.
Subsultus tendinum and contraction of muscles.
Bones sensitive; bones of legs brittle; caries of spinal vertebrae; pains in joints as if crushed; arthritis; tophi on knees and feet.
Scrofulosis; fistula; carbuncles.
Open cancer.
Swelling of whole body, which turns a deep yellow.
Swelling of body like hydrops, with great oppression.


Small wounds suppurate much.
Tendency of wounds to suppurate, with throbbing and lancinating pains.
Lymphatics swell after a wound.
Depression of skull from a horse's kick on occiput. ~ Epilepsy.
Convulsions after having teeth extracted. ~ Epilepsy.
When suppurations seem to be the cause of convulsions. ~ Epilepsy.
Touch: tenderness of forehead and vertex; ovarian region sensitive.

SKIN. [46]

Stitches in skin prevent sleep at night. ~ Softening of brain.
Red or purplish streaks in neck, back or other parts. ~ Meningitis.
Yellow color of skin.
Skin greenish, dirty, oily, or greyish-yellow. See 36.
Erysipelatous eruptions.
Pustules, tetters and eruption of small nodules.
Large yellow blisters, like pemphigus, mostly on palms of hand and soles of feet; burning.
Pompholyx in hand returning every year.
Phlyctenoid eruption, discharging a thin, yellow fluid, similar to that appearing in vomit and leucorrhea. ~ Epilepsy.
Moist tetters, with suppurating places resembling flat ulcers, in mane of horses.
Bluish-black swelling around (thumb) nail, followed by suppuration. ~ Panaritium.
Ulcers, with burning pains.
Malignant pustule.
Carbuncles; blue far around.
Carbunculus pestilentialis.


Boy, aet. 6, inclination to touch genitals.
Boy, aet. 11, good constitution; epileptic attack six months ago, without apparent cause.
Woman, aet. 30, wreck in mind and body from epilepsy.
Woman, aet. 40, suffered thirty years with epileptic spasms.
Woman, aet. 24, suffered for more than a year with epilepsy.
Child, aet. 6, had some poison spirted into his right eye by a toad, during a dry, hot June day in Rome.


Antidoted by: Laches., Senega.
Compare: In convulsions from low grades of suppuration, Arsen., Canthar., Laches., Tarent.; in epilepsy, aura starting in solar-plexus, Artem., Calc. ost., Nux vom., Silica; aura starting in arm, Laches., Sulphur; in chorea, patient cannot walk, must run or jump, Kali brom., Natr. mur.; in masturbation, impotence, etc., Hyosc., Mercur., Sulphur; in malignant pustule, Antim. crud., Laches.; in bullae, panaritia, etc., Hepar, Laches., Phosph. ac., Silica.
Cubebae is similar to Bufo (Lippe).
Complementary: Salamandra (epilepsy, cerebral softening).


Source: The Guiding Symptoms of Our Materia Medica Vol. 03, 1881
Description: Clinical materia medica of Bufo rana
Remedies: Bufo rana
Author: Hering, C.; Raue, C.G.; Knerr, C.B.; Mohr, C.
Year: 1881
Editing: errors only; interlinks; formatting
Attribution: Legatum Homeopathicum
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